Epithalon
COA published
A synthetic tetrapeptide studied in telomere-biology and cellular-senescence research.
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MOTS-c
A mitochondrial-derived peptide studied in metabolic-signalling and cellular-energetics research.
- Test methods
- HPLC-UV + LC-MS
- Purity target
- 99%+ verified
- Sizes available
- 2
- Availability
- In stock
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Quantity
1
Total
$54.00
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Certificate for this lot is pending. Every batch we ship is published at /coa before it goes out.
For Research Use Only. Not for Human Consumption.
Products supplied by Synthrex Biotech LLC are intended strictly for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics, or dietary supplements, and are not approved by the FDA for human or veterinary use. They are not sold for, and must not be used for, human or animal consumption or administration of any kind. Synthrex Biotech LLC is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under section 503B of that Act. By purchasing, you affirm that you are a qualified researcher acquiring these materials for lawful research purposes only. A Safety Data Sheet (SDS/MSDS) is available on request for every compound.
Sold by Synthrex Biotech LLC. A Safety Data Sheet (SDS) is available on request at support@synthrexbiotech.com.
✦ Research Notes
Background & literature
Origin
MOTS-c belongs to a genuinely novel category: mitochondrial-derived peptides, encoded not in nuclear DNA but in the mitochondrial genome itself. It is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, identified by Pinchas Cohen’s group at USC and reported in Cell Metabolism in 2015. The discovery mattered beyond the molecule: it established that the mitochondrial genome encodes signalling peptides that act on the rest of the cell, which was not the prior understanding of what mitochondrial DNA does.
What has been characterised
Characterised as a regulator of cellular energy homeostasis, with published work in mice and cell culture describing effects on the AMPK pathway and folate–methionine cycle intermediates. The founding 2015 Cell Metabolism paper reported its characterisation in murine models. A 2023 review in Frontiers in Endocrinology surveys the subsequent literature. All preclinical — rodent and cell-culture. Not FDA-approved for any use.
Sources
- 1.Cell Metabolism, 2015. PMID 25738459 — the founding publication identifying MOTS-c as a mitochondrial-derived peptide (title not reproduced here; this site does not publish body-composition language)
- 2.“MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.” Front Endocrinol (Lausanne), 2023. PMID 36761202
These notes are provided for scientific context only. They describe published laboratory and preclinical research and are not a claim of any effect in humans. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Related Compounds
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.