Selank
COA published
A tuftsin-derived heptapeptide investigated in anxiolytic and nootropic research literature.
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Semax
CAS80714-61-0
An ACTH(4-10) analog studied in neuroprotection and cognitive-pathway research.
- Test methods
- HPLC-UV + LC-MS
- Purity target
- 99%+ verified
- Sizes available
- 2
- Availability
- In stock
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Quantity
1
Total
$46.00
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Certificate for this lot is pending. Every batch we ship is published at /coa before it goes out.
For Research Use Only. Not for Human Consumption.
Products supplied by Synthrex Biotech LLC are intended strictly for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics, or dietary supplements, and are not approved by the FDA for human or veterinary use. They are not sold for, and must not be used for, human or animal consumption or administration of any kind. Synthrex Biotech LLC is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under section 503B of that Act. By purchasing, you affirm that you are a qualified researcher acquiring these materials for lawful research purposes only. A Safety Data Sheet (SDS/MSDS) is available on request for every compound.
Sold by Synthrex Biotech LLC. A Safety Data Sheet (SDS) is available on request at support@synthrexbiotech.com.
✦ Research Notes
Background & literature
Origin
Semax is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. It is built from ACTH(4–10) — a fragment of adrenocorticotropic hormone already known to be behaviourally active but rapidly degraded — with a Pro-Gly-Pro tail added at the C-terminus specifically to slow enzymatic breakdown. Critically, the fragment was chosen because it lacks the corticotropic activity of full-length ACTH: the design intent was to keep the neuroactive portion and discard the hormonal one. It is listed in the Russian pharmacopoeia but has never been approved by the FDA or EMA.
What has been characterised
The characterised biology sits in two areas. First, ACTH(4–10)-derived peptides interact with melanocortin receptors and with BDNF expression in rodent brain tissue. Second — and less widely appreciated — the N-terminal acetylation state of Semax substantially changes its coordination of copper(II) and zinc(II) ions, which a 2016 study in J Inorg Biochem tied to its biological properties. A 2021 rodent study examined behavioural and neurochemical measures following early-life fluvoxamine exposure. This is animal and in-vitro work; Semax is not FDA-approved for any use.
Sources
- 1.“Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.” J Inorg Biochem, 2016. PMID 27586814
- 2.“Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.” Neuropeptides, 2021. PMID 33418449
These notes are provided for scientific context only. They describe published laboratory and preclinical research and are not a claim of any effect in humans. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Related Compounds
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.