BPC-157
COA published
A synthetic pentadecapeptide studied in in-vitro models of tissue-repair signalling and cellular migration.
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IGF-1 LR3
A long-arginine IGF-1 analog studied in cellular-proliferation research.
- Test methods
- HPLC-UV + LC-MS
- Purity target
- 99%+ verified
- Sizes available
- 1
- Availability
- Backordered
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Quantity
1
Total
$145.00
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Certificate for this lot is pending. Every batch we ship is published at /coa before it goes out.
For Research Use Only. Not for Human Consumption.
Products supplied by Synthrex Biotech LLC are intended strictly for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics, or dietary supplements, and are not approved by the FDA for human or veterinary use. They are not sold for, and must not be used for, human or animal consumption or administration of any kind. Synthrex Biotech LLC is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under section 503B of that Act. By purchasing, you affirm that you are a qualified researcher acquiring these materials for lawful research purposes only. A Safety Data Sheet (SDS/MSDS) is available on request for every compound.
Sold by Synthrex Biotech LLC. A Safety Data Sheet (SDS) is available on request at support@synthrexbiotech.com.
✦ Research Notes
Background & literature
Origin
IGF-1 LR3 is a modified recombinant analog of insulin-like growth factor 1, carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Both modifications serve the same purpose: they sharply reduce binding to the IGF binding proteins (IGFBPs) that normally sequester circulating IGF-1. Since roughly 98% of native IGF-1 in circulation is bound to IGFBPs at any moment, an analog that escapes them behaves very differently as a laboratory reagent — which is why LR3 became a standard supplement in mammalian cell-culture media.
What has been characterised
Characterised as an IGF-1 receptor agonist with markedly reduced IGFBP affinity. Published work has compared the differential effects of IGF-1 and gonadotropins on proliferative activity in distinct granulosa cell subgroups, and examined interactions between follicle-stimulating hormone and growth factors in DNA synthesis in bovine granulosa cells — cell-culture studies of the receptor system this analog engages. Not FDA-approved for human use; IGF-1 and its analogs appear on the WADA Prohibited List.
Sources
- 1.“Differential effects of insulin-like growth factor-I and gonadotropins on the proliferative activity of two subgroups of granulosa cells: cumulus oophorus and mural granulosa cells.” Fertil Steril, 2001. PMID 11334915
- 2.“Interactions between follicle-stimulating hormone and growth factors in regulation of deoxyribonucleic acid synthesis in bovine granulosa cells.” Biol Reprod, 1997. PMID 9283008
- 3.WADA Prohibited List — World Anti-Doping Agency
These notes are provided for scientific context only. They describe published laboratory and preclinical research and are not a claim of any effect in humans. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Related Compounds
TB-500
COA published
A thymosin beta-4 fragment investigated in research on cellular migration and angiogenesis pathways.
$50.00View
BPC-157 + TB-500 Blend
COA published
A combined preparation of BPC-157 and TB-500 used in comparative tissue-repair research models.
From$90.00Select size
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.