PT-141 (Bremelanotide)
A melanocortin-receptor agonist studied in central nervous system pathway research.
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Kisspeptin-10
CAS374675-21-5
A KISS1-derived peptide investigated in reproductive-axis signalling research.
- Test methods
- HPLC-UV + LC-MS
- Purity target
- 99%+ verified
- Sizes available
- 1
- Availability
- Backordered
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Quantity
1
Total
$42.00
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Certificate for this lot is pending. Every batch we ship is published at /coa before it goes out.
For Research Use Only. Not for Human Consumption.
Products supplied by Synthrex Biotech LLC are intended strictly for in-vitro laboratory research and development by qualified professionals. They are not drugs, foods, cosmetics, or dietary supplements, and are not approved by the FDA for human or veterinary use. They are not sold for, and must not be used for, human or animal consumption or administration of any kind. Synthrex Biotech LLC is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under section 503B of that Act. By purchasing, you affirm that you are a qualified researcher acquiring these materials for lawful research purposes only. A Safety Data Sheet (SDS/MSDS) is available on request for every compound.
Sold by Synthrex Biotech LLC. A Safety Data Sheet (SDS) is available on request at support@synthrexbiotech.com.
✦ Research Notes
Background & literature
Origin
Kisspeptin has one of the better naming stories in biochemistry. The parent gene KISS1 was identified in 1996 as a metastasis-suppressor in Hershey, Pennsylvania, and the researchers named the product “kisspeptin” after Hershey’s Kisses. Its role as the upstream regulator of GnRH release was discovered separately and later, when loss-of-function mutations in its receptor GPR54 were found in patients with hypogonadotropic hypogonadism. Kisspeptin-10 is the C-terminal decapeptide fragment that retains full receptor activity.
What has been characterised
Characterised as an agonist at KISS1R (GPR54), a G-protein-coupled receptor, positioned upstream of GnRH neurons in the hypothalamic-pituitary-gonadal axis. Published work has examined kisspeptin-10 binding to Gpr54 in osteoclasts with respect to Dusp18-mediated dephosphorylation of Src, and studied KISS1/KISS1R expression in prostate tissue. Animal and cell-culture research. Not FDA-approved for any use.
Sources
- 1.Nat Commun, 2024. PMID 38346942 — Gpr54 binding in osteoclasts and Dusp18-mediated dephosphorylation of Src (title not reproduced here)
- 2.“Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer.” Anticancer Res, 2020. PMID 32014912
These notes are provided for scientific context only. They describe published laboratory and preclinical research and are not a claim of any effect in humans. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Related Compounds
Melanotan I
A melanocortin analog studied in receptor-binding and pigmentation-pathway research.
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Melanotan II
A melanocortin-receptor agonist analog studied in receptor-binding research.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.