Growth Hormone Secretagogue Peptides

This is the largest and oldest-characterised class on the site, and it splits cleanly in two. The GHRH analogues — Sermorelin, CJC-1295, Tesamorelin — are built on the growth-hormone-releasing hormone sequence that Roger Guillemin and Andrew Schally raced to isolate in the 1970s, work that took a Nobel Prize in 1977. Sermorelin is the shortest fragment that retains receptor activity; the later analogues add substitutions and acyl groups for protease resistance and half-life. The second half acts somewhere else entirely: Ipamorelin, Hexarelin and the GHRPs are ghrelin-receptor (GHS-R1a) agonists, a receptor identified in 1996 before anyone knew what bound it — the endogenous ligand, ghrelin, was not found until 1999. Two receptors, two pharmacologies, one endocrine axis. All characterisation here is animal and in-vitro.

5 compounds · For Research Use Only. Not for Human Consumption.